Profanities in spanish (specially in Mexico), depends a lot in the context and/or the person they're referring to. They can be really insulting or very friendly. Something like the word "c*nt", but in a wide way: it can be used in AUS only with really good friends while in the US it can be a really hard insult.

Cabrón, in the way Satori (or Mefo) is using it, it's in a very friendly way. It can be weird as that.

I kinda see it as "What's up bitches"

Not super friendly, but like a backhanded greeting.

"...refers to a man whose wife was unfaithful to him"

Satori is literally calling us cucks.